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McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, et al

The trial reported no adverse events

Andreeff M , Konopleva M, Zhao S, Leysath C, Carter B, Milella M, Weidner D, Lapillonne H, Tabe Y, Schober W, Hu W, Heiss P, Estey E, Huang Z, Kornblau S

However, LDHB silencing did not result in a dramatic increase in cellular ROS levels

Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug th-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma

Nicotinamide adenine dinucleotide (NAD) is a coenzyme molecule that plays a central role in cellular bioenergetic processes