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doi: 10.5847/wjem.j.1920-8642.2018.01.011 [PubMed]

Adverse effects observed in trials include: Nausea and vomiting particularly during dose escalation Diarrhoea or constipation Decreased appetite Injection site reactions Fatigue and dizziness Gallbladder-related events (including gallstones), consistent with effects observed with other GLP-1based therapies [9] Rare cases of pancreatitis , a risk associated with the GLP-1 receptor agonist class [10] [3] Because retatrutide is not licensed in the UK, the MHRA has not issued specific prescribing or dosing guidance for this compound

The LEV+VPA regimen also demonstrated some degree of risk, though this did not reach statistical significance (OR = 1.17, 95% CI [0.93, 1.45], P = 0.181) (see Figure 3B)

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