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Some research suggests that the inflammatory cascade triggered by chronically elevated homocysteine may lower the threshold for anxiety and depressive episodes in susceptible individuals

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Health Conditions Certain health conditions, such as digestive disorders (like Crohn's disease or celiac disease), can impair the absorption of B12

Some doctors claim that when the B12 injections are given to these patients that symptoms can improve and it can delay the progression of the condition

Therefore, combining fosphenytoin and lacosamide may increase toxicity without providing significant improvement in efficacy