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The FDA's own framing is that a drug may be compounded for a patient who cannot be treated with an FDA-approved medication, and that compounded drugs should only be used in patients whose medical needs cannot be met by an FDA-approved drug

A few studies also suggest that GLP-1 RAs may increase fertility in men, particularly those with obesity, by improving semen concentration, motility, and morphology

Effect of sex and obesity on basal VLDL-triacylglycerol kinetics

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Interestingly, exendin-4 (939), an antagonist of GLP-1R (Avexitide, Phase III), has been shown earlier to bind to the ECD of GLP-1R with an orientation different than that of GLP-1