Lowers inflammation by blocking the production of most inflammatory cytokines
Additionally, TB-500 reduces formation of fibrotic scar tissue, a common consequence of excessive inflammation, resulting in more functional repaired tissue
The mechanism may be related to curculigoside significantly reducing AD-promoting factors (e.g., A1-42, p-tau) and increasing ferroptosis protective factors (e.g., GPX4, SLC7A11, GSH) in the hippocampus and cortex of AD mice, 574 suggesting that the natural compound curculigoside can be used as a promising therapeutic agent to improve AD by inhibiting ferroptosis
For example, glutamatepyruvate transaminase (GPT, also known as alanine aminotransferase) transfers a nitrogen from glutamate to pyruvate to make alanine and -ketoglutarate
PloS One (2021) 16(5):e0251135
Storage Store unreconstituted vials at 2 8 C in the refrigerator