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Nasal sprays can contribute to smell loss through the following mechanisms: Damage to Nasal Lining: Prolonged use of decongestants can irritate and inflame the nasal lining, impairing olfactory receptors

In a study using a lymphoblastoid cell line from patients with late-onset alzheimers disease, catalpol activates the Kelch-like ECH-associated protein 1 (Keap1)/Nrf2/antioxidant response element (ARE) signaling pathway, providing antioxidant and anti-apoptotic effects (Xiang et al., 2024)

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