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Most target organs (heart, brain, peripheral vasculature) are affected by both diabetic macrovasculopathy and microvasculopathy

All the aforementioned problems make the case for the need for auxiliary imaging modalities

The results showed that more patients treated with liraglutide achieved resolution of MASH than did those treated with placebo, but there was no significant difference in fibrosis improvement

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The OINDP classification is important because it signals that standard pharmaceutical testing protocols are insufficient nasal sprays require a specialized suite of device performance tests (spray pattern, plume geometry, droplet size distribution, dose uniformity) that are specific to this dosage form and that are detailed in dedicated FDA guidance documents