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Here, they undergo incomplete, alternative oxidation pathways that generate massive amounts of free radicals and reactive oxygen species (ROS), further damaging the delicate mitochondrial membranes and the very enzymes required for energy production

Neural stem cells and the developing brain When we examined the effect of TMLHE mutations in mice, we found these mutations specifically affect neural stem cells during early stages of brain development

thus, depleted levels of Myo may cause the pathogenesis of thyroid diseases such as hypothyroidism (187)