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10.1371/journal.pone.0188136 PLoS One 114 LingvayI.CatarigA

Cryo-EM structural studies published in 2024 confirmed how a single peptide can adopt the conformational geometry required to activate all three receptor types, with each binding interaction producing measurable cAMP-mediated intracellular responses [9]

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After cellular injury occurs, PINK1 transmits signals to the cytosolic E3 ubiquitin ligase referred to as Parkin

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