The plasma half-life is estimated at 30-60 minutes, though biological effects on gene expression persist for hours to days
Thus, careful consideration of patient groups and inflammatory status is essential when employing prolonged antifungal regimens
Finally, we are developing new technologies, such as genetic knockout and high throughput transgenesis, for zebrafish in order to better address fundamental questions raised in our biological studies
Most therapies are weekly, some bi-weekly and maintenance therapies are often monthly
Engineering of primary human T cells and in vitro killing assay Engineered TCR and CAR receptors recognize the NY-ESO-1 157165 peptide presented by HLA-A*02:01
In the canonical GPX4-dependent pathway, p53 suppresses SLC7A11 to reduce cystine uptake, leading to GSH depletion and impaired GPX4 activity, thereby promoting ferroptosis