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The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4

The purpose of gradual titration is to minimize side effects with dose escalation and achieve therapeutic levels

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In the Phase 2 trial, the majority of weight lost was fat mass

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