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For individuals with Wilson's disease (a genetic disorder causing copper accumulation) or other copper metabolism disorders, theoretical caution is warranted, though even in these populations topical GHK-Cu is unlikely to pose significant risk given the minimal systemic absorption

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Too much copper and too little zinc can amplify oxidative stress, strain the brains antioxidant defenses, and interfere with neurotransmitter balance

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Interaction with Medications Glutathione supplements may interact with certain medications, including chemotherapy drugs and nitroglycerin