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If the goal is sports-related and "pre-sport" intake is too restrictive, post-workout intake is often more sustainable

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This is particularly relevant for medications with narrow therapeutic windows

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1 could demonstrate that glutathione (GSH) transport seems to be mediated by SLC25A39, since loss of SLC25A39 reduces mitochondrial GSH import and abundance without affecting cellular GSH levels

Insulin resistance can paradoxically develop during extended cycles as chronic IGF-1 receptor activation triggers compensatory IRS-1 phosphorylation at inhibitory sites this is why insulin sensitizer co-administration becomes more important in cycles longer than 6 weeks