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Saint-Cyr M, Langstein HN

[97] who found basal glycolysis to be reduced in both CD4 + and CD8 + T cells in ME/CFS

Lehrer RI, Ganz T: Defensins: endogenous antibiotic peptides from human leukocytes

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At the same time, pyruvate accumulation stabilizes and activates hypoxia-induced factor-1 (HIF-1) (even in the bodys physiological oxygenated state) which increases oxidative stress and induces an inflammatory response in the form of, for example, activation of nuclear factor kappa-B (NF-B) and increased expression of tumor necrosis factor- (TNF-) [60,61] (Figure 3)

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