GI-related adverse events were most prevalent during the first week of treatment, with observed rates generally declining through the remainder of the study
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[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Zimmermann MB, Muthayya S, Moretti D, Kurpad A, Hurrell RF
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Moreover, the mitochondrial dysfunction narrative still leaves unresolved the insulin sensitizers riddle, whereby anti-diabetic agents that promote sensitization to insulin e.g., biguanides / metformin, thiazolidinedioones / pioglitazone, high-dose aspirin, berberine and others, are all reported to act as mitochondrial complex I inhibitors [84], implying that mitochondrial dysfunction is more of a solution rather than a problem in the T2D context [85]
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