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All of the extant genotypes appear to have evolved from genotype 1 subtype 1b

I highly recommend the research of Dr Thomas Seyfried and team on cancer as a metabolic disease

No participants withdrew due to adverse events

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Systemic causes Diabetes Obesity Hypothyroidism Pregnancy Menopause Systemic lupus erythematosus Scleroderma Dermatomyositis Renal failure Long-term hemodialysis Acromegaly Multiple myeloma Sarcoidosis Leukaemia Alcoholism Haemophilia PATHOPHYSIOLOGY The most popular ones are mechanical compression, micro-vascular insufficiency, and vibration theories

Smokers are at increased risk of respiratory, cardiac and wound-related complications following surgery