As lignan metabolites bind to estrogen receptors, they affect estrogen function, reducing their circulation in the bloodstream and their biological activity, thereby reducing breast cancer risk [113,114]
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SARS-CoV-2 has been found to replicate in the gastrointestinal tract and potentially spread to other sites, such as the lungs, through its impact on inflammatory regulation and ACE2 expression in the gastrointestinal tract ( Enterobacteriaceae , and community-acquired pneumonia (CAP) ( However, the causal relationship between gut microbiota dysbiosis and pulmonary infections could potentially be bidirectional: in immunosuppressed or chronically ill patients, microbiota dysregulation may enhance susceptibility to pneumonia by impairing mucosal immunity
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