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People with the APOE4 gene variant appear to have more oxidative stress and lower reduced glutathione in brain tissue

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EC 6.3.2.2) catalyzes formation of -glutamylcysteine from cysteine and glutamate

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However, a one-year randomized, double-blind, placebo-controlled trial in 253 elderly (65 years) adults with elevated homocysteine levels found that B vitamin supplementation (1,000 g/day of folate, 10 mg/day of vitamin B 6 , and 500 g/day of vitamin B 12 ) did not improve measures of cognitive function, including memory, despite lowering homocysteine levels (116)

But the data showing a quick rise in cellular glutathione levels means the product could have a future sports nutrition applications as well