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In 2015, Obeid et al

PMID: 31905796

It has been suggested that at elevated temperatures a specific repressor of riboflavin biosynthesis is activated, although no direct evidence has been presented

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There was no statistically significant difference between amlodipine besylate and placebo in the primary endpoint of all-cause mortality (95% confidence limits from 8% reduction to 29% increase on amlodipine besylate)