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To check if the drop in tumor cysteine levels was responsible for the tumor reduction, we repeated the experiment but we now supplemented the mice with N-acetyl-cysteine, which partially reversed the effect of the GGT inhibitor

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In Nrf2 knockout rats, the constitutive activity of the choroidal glutathione-dependent detoxifying machinery is maintained, but the efficacy of dimethylfumarate to induce glutathione conjugation in the choroid plexuses is strongly reduced, indicating that dimethylfumarate acts mainly through the Nrf2 signaling pathway

It can also be shown that: Here T , S and H are respectively the temperature at the melting point, change of entropy of melting and the change of enthalpy of melting

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