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54% for SGLT2i and 50% for DPP4i)
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That means the overall clearance timeline (45 weeks for most of the drug) is broadly similar across doses
Managing hydration on GLP-1 treatments Preventative strategies Increase fluid intake to at least 2-3 litres daily (unless contraindicated) Monitor urine colour aim for pale yellow as an indicator of good hydration Establish a regular drinking schedule rather than relying on thirst Use oral rehydration solutions if experiencing significant fluid losses Track daily fluid intake using a dedicated water bottle or app Dietary considerations Consume hydrating foods (fruits, vegetables, soups, broths) Replace electrolytes lost through vomiting or diarrhoea Limit caffeine and alcohol which can worsen dehydration Consider small, frequent sips if nausea makes drinking difficult Include foods with high water content like cucumber, watermelon, and celery Monitoring approaches Weigh yourself regularly rapid weight loss may indicate fluid loss Check for skin turgor by pinching skin on the back of hand
J., Rodrguez-Martn, A., Torres, E., Velasco, I., Rodrguez, A
Thus, it appears that GLP-1 analogues may affect feeding behaviour both through central and peripheral effects
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