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Human clinical trials for Motus reported about 10.4 percent average weight loss over six months which is noteworthy for a supplement and reinforces that oral options can be meaningful when supported by lifestyle

Johnson, M.R., et al

The Trp64Arg variant, present in 8-12% of the population, is associated with reduced beta-3 receptor function and may blunt AOD-9604's effects

When you fill out the eligibility form, indicate whether youve been on weight loss medication in the last 6 months

For instance, in September 2025, the World Health Organization (WHO) updated its Model Lists of Essential Medicines (EML)

[DOI] [PubMed] [Google Scholar] Sharma P, Dubey RS