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1 H-NMR urine metabolomics, excluding TMA and dimethylamine, was the worst predictor explaining 1.5% of TMAO variance and correcting for urinary creatinine, computed by 1 H-NMR (Methods), did not improve predictions explaining 1% of TMAO variance on average (Supplementary Fig

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The development of depression-like behavior is consolidated by IL-6-induced activation of locus coeruleus neurons and IL-1-induced elevated leptin levels in mice

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Micah Eimer, a clinical assistant professor at Northwestern Medicine and senior author of the study, said the research was inspired by a pattern he noticed among patients taking GLP-1 medications