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a) In contrast to the 20mer MOE-ASO, the 20mer containing LNA wings accumulated already at 10 nM in nuclear foci and shifts to the nucleoli at the highest concentration (100 nM)

Clinical Pharmacokinetics, 57 (12), 15291538

Blood 98(12):34973500 McNulty H, Dowey LRC, Strain JJ, Dunne A, Ward M, Molloy AM, McAnena LB, Hughes JP, Hannon-Fletcher M, Scott JM (2006) Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677CT polymorphism

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This move was strategic: cut the price significantly (down to $349/month for maintenance doses) to increase patient volume, especially in the massive cash-pay segment

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