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Pharmacol Rev 2000
Receptor dynamics play a crucial role, as prolonged exposure to IGF1 LR3 can lead to receptor downregulation or desensitization of signaling pathways
They are all small molecules which act as reversible competitive inhibitors of the catalytic activity of DPP-4 and, when used at the appropriate therapeutic dose, are associated with at least 70% inhibition of plasma DPP-4 activity (35) (although the actual extent of inhibition in vivo is likely to be higher, due to dilution of the inhibitor in the ex vivo assay)
Status Not FDA-approved as of June 2026
Sarah dealt with nausea, stomach discomfort, and acid reflux - all common side effects during the initial phase