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Detailed analysis of atpenin A5 and phenformin cytotoxicity and inhibition of metabolic activity in various cell lines As predicted from our modeling approach as tier 1 targets, atpenin A5 at 20 M and phenformin at 100 M do not show toxicity in endpoint measurements based on total cell counting when Calu-3, CaCo-2, A549, and Huh7.5 cells were exposed to the compounds for 72 h (Fig
doi: 10.1016/j.tips.2023.07.004
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However, the absence of evidence for interactions is not evidence of safety, as no controlled studies have evaluated this combination
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
A 2021 Nature Communications study then showed that MOTS-c is induced by exercise and that treating mice, including animals started late in life, boosted running capacity and physical performance across young, middle-aged, and old groups [3]
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