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M., Lehto, S., Ronnemaa, T., Pyorala, K

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doi: 10.3390/biology11020239 214 HansonPMYangRYWuJChenJTLedesmaDTsouSCet al

Our previous study demonstrated that the activity of CPT I, a key mediator in the -oxidation of fatty acids, is decreased in the mitochondria of the livers of mice with cachexia liver, and is increased by L-carnitine (3)

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355 The pro-inflammatory cytokines, in turn, augment both mitochondrial and NOX-generated ROS, contributing to further accumulation of oxidative damage (Fig