Jeffrey Lee, MD, a double board-certified plastic surgeon and founder of JL Plastic Surgery in Boston, MA, who was not involved in the study, spoke to Healthline about these hidden side effects, why they may occur, and what people may misunderstand about GLP-1s from social media posts
ROS damage the tissues, especially through lipid peroxidation [26]
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Are GLP-1 drugs suitable for Type 1 diabetes
Its actions, however, are highly context-dependent, and under conditions of NAD + depletion, specific cell types, dosing imbalances, or advanced disease, SIRT1 may exacerbate oxidative damage by impairing repair enzyme activity, exacerbating mitochondrial dysfunction, and weakening antioxidant responses
2023, doi: 10.1001/jama.2023.12055
