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Peroxynitrite is highly toxic to neurons and causes hyper-excitability of the central nervous system, a process known as "kindling." This leads to autonomic nervous system dysfunction (dysautonomia), sensory overload, and severe cognitive deficits

However, a systematic CSF-related dilution would be expected to affect all metabolites proportionally, which is not consistent with the heterogeneous pattern observed in the present study

2.2 mg dose from a 20 mg vial: Target 25 units (0.25 mL)

According to the FDA prescribing information, gastrointestinal adverse reactions are very common, with nausea (24-37%), diarrhea (18-26%), vomiting (8-25%), and constipation (16-24%) occurring frequently across clinical trials

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Int J Tryptophan Res 7:1522