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The most common cause is overuse or repetitive injury, and it has been reported to occur in athletes of virtually every sport

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Likewise, a Pycnogenol metabolite was observed to be subjected to facilitated uptake via GLUT-1 transporters into erythrocytes and endothelial cells (19, 20)

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Given that stem cells are core drivers of organismal aging, health and longevity, a greater understanding of these NRF2-based aspects may make it possible one day to rejuvenate tissues in older individuals, thereby increasing human healthspan and perhaps lifespan