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Sharma et al., 2013)

Strategies to minimize reactions include rotating injection sites consistently to avoid repeated trauma to the same area, ensuring the solution is at room temperature before injection (cold injections can increase irritation), injecting slowly rather than quickly, and using a smaller gauge needle for less tissue trauma

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But that has not tamped down the demand

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Adenyl cyclase and cyclic adenosine monophosphate (cAMP) are suppressed by activating the receptors of MT1 and MT2, which decreases the absorption of linoleic acid, a source of tumor growth [18, 19]