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However, we did not find a dose-dependent change in average drinks or AUDIT scores in the medication groups, although a visual downward trend could be observed in the Tirzepatide group

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The isoform of this enzyme (PI3K) is also involved in insulin signaling, and the inhibition of this pathway by either pan-PI3K inhibitors (i.e., copanlisib and duvelisib) or specific PI3K inhibitors (i.e., alpelisib and inavolisib) can lead to hyperglycemia (250)