This study was supported by Eli Lilly and Company
Animal models of myocardial infarction show that TB-500 administration improves left ventricular function, reduces infarct size and cardiomyocyte death during ischemic events, and enhances cardiac microvascular density to improve tissue perfusion
The presenting author(s) of the original presentation had no involvement in the creation of this content
Hagen TM, Wierzbicka GT, Bowman BB, et al
Experiments in islet cell models have shown that intracellular signalling after GLP-1R agonist binding occurs via two pathways, one of which (cyclic adenosine monophosphate generation) enhances insulin release, while the other (-arrestin recruitment) causes GLP-1R receptor internalisation, and hence reduces cellular sensitivity to ligand
But transformative nonetheless