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If the data matters, the details matter

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J.KarthikaR.RosanaO

Here, we examine how a high-fat diet (HFD) that promotes AGE generation impairs male reproductive health in mice and evaluate two representative interventions with distinct mechanisms: Alagebrium (ALT-711), an AGE cross-link breaker 67 , and Fertilix, a commercial antioxidant fertility supplement 68

Several pro-angiogenic factors were increased, including IL-6, IL-1, VEGF-D, VEGFR2, C-X-C motif chemokine ligand 11 (CXCL11), urokinase plasminogen activator surface receptor (uPAR), monocyte-chemotactic protein 3 (MCP-3), basic fibroblast growth factor (bFGF), tumor necrosis factor-alpha (TNF-) and MMP-9, and chemokine (C-C motif) ligand 5 (CCL5 or RANTES) (108)

Encapsulated glutathione brightens uneven tone and dullness