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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus (under the brand name Mounjaro) and chronic weight management (under the brand name Zepbound)

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The FDA subsequently granted the APR-246 orphan drug name and approved APR-246 for MDS treatment