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458 Inflammatory cytokines and autoantibodies implicated in RA pathogenesis can activate ER stress pathways, which in turn drive inflammatory responses that contribute to disease progression

PC, an irreversible oxidative modification (88), is classified into two types based on the origin of the carbonylated product (Figure 2)

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Flavor constituents of beef as influenced by forage- and grain-feeding

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Under oxidative stress conditions, apoptosis signal-regulating kinase 1 (ASK1) dissociates from its inhibitory protein, thioredoxin (Trx), resulting in its activation and initiating the downstream JNK/p38 MAPK apoptotic pathway (89)