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Precaution is necessary since pregnancy risks are unknown

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According to the release from Johnson & Johnson , for the treatment of UC, guselkumab is administered as a 200 mg induction dose intravenously at weeks zero, 4, and 8 by a healthcare professional

231 UBE3A modulates excitatory synapse development by regulating the degradation of ARC, which reduces LTP by promoting the internalization of AMPA receptors