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MIA, an inhibitor of glyceraldehyde-3-phosphate dehydrogenase, can disrupt chondrocyte glycolysis and ultimately lead to cell death, thereby contributing to cartilage degradation, subsequent alterations in subchondral bone, and the development of osteophytes 25,34

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doi: 10.1021/acschemneuro.1c00146 46

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The formula Concentration (mg/mL) = Vial Amount (mg) / Water Added (mL) Units to Draw = (Target Dose mg / Concentration mg per mL) x 100 Best configurations by dose range For 1-4mg doses: 10mg vial + 2mL water = 5mg/mL

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