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The three studies highlighted in this section utilize Cu 2+ /Cu + redox reactions to elevate O 2 levels and lower reductive GSH levels ( Figure 5A ) (155), Mn 4+ /Mn 2+ redox reactions to increase O 2 levels and decrease GSH levels ( Figure 5B ) (166), and the cycling between Cu 2+ and Cu + ions to regulate H 2 O 2 and GSH levels along with hydroxyl radical concentrations ( Figure 5C ) (167)

10.1074/jbc.M110.121327 155 ManeaA.ManeaS

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