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It increases the risk for multiple metabolic complications including type 2 diabetes (T2D), metabolic-dysfunction associated steatotic liver disease (MASLD, previously known as non-alcoholic fatty liver disease), cardiovascular disease as well as many mechanical complications such as osteoarthritis and obstructive sleep apnoea (OSA) [3]

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Starting Requirements Age 16 or older BMI at/above the 95th percentile or 85th percentile with a weight-related health concern (e.g

The large 2025 JACC meta-analysis of 99,599 patients found consistent MACE reduction regardless of whether patients had diabetes, obesity, CKD, or heart failure