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Permanent damage is rare

The clinical trials of anti-obesity medications like Wegovy and Zepbound included structured lifestyle programs along with the medication, which are advised along with every new prescription

A brief overlap-free transition period, stopping the injectable and allowing washout before starting orforglipron, prevents excessive GLP-1 receptor stimulation

Although the role of bombesins in modulating mucus secretion or muc5AC/muc5B regulation in COPD is unknown, given that bombesins are increased in COPD [193] and muc5B is also increased [188], then it is possible that either a direct or indirect relationship between bombesin signaling and muc5B expression exists

Fraternale et al., 2017

Slowing the climb is the main lever