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The expansion of water as it turns to ice can potentially stress the glass vial, leading to microfractures and compromising the seal

Further research on the effects of MS drugs on cobalamin levels is crucial to optimize treatment strategies and minimize potential vitamin B12-related complications in patients undergoing MS therapy

Advanced Handling Storage optimisation: Use desiccants, log temperatures, avoid fluctuations

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MK: Writing review & editing

FDA considers the physical and chemical characterization of the substance, safety issues, available evidence of effectiveness or lack of effectiveness, and historical use in compounded products