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Furthermore, in a BK5.IGF-1 mouse model of breast cancer, elevated levels of IGF-1 expression activated the COX-2/PGE2/EP3 signaling pathway, accompanied by increased VEGF expression and tumor angiogenesis (110)

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10.5138/ijpm.2010.0975.0185.02031 40 LeoneA.SpadaA.BattezzatiA.SchiraldiA.AristilJ.BertoliS

doi: 10.1002/jbm.a.37118 173 BeskidNMKolewoleECoronelMMNguyenBEvavoldBGarcaAJet al

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Because Glutathione-producing supplements are ingested by pill, gastrointestinal disturbances such as diarrhea, nausea, or vomiting can occur