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[12] reported that GLP-1 agonists dose-dependently increased blood pressure and heart rate in rats probably via activation of neurons in autonomic control sites in the brain, including medullary catecholamine neurons that provide input to sympathetic preganglionic neurons

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Depression can reduce libido and make sexual activity less appealing

However, some of the medication's known side effects, like nausea, dehydration, or changes in blood sugar, can trigger headaches indirectly, which may be why headaches have been reported as a post-approval side effect

These mechanisms operate through distinct biological pathways, meaning they theoretically complement rather than compete

Strategies to Prevent Weight Regain Without Constant Stopping The most effective approach is uninterrupted semaglutide therapy at a maintenance dose that keeps appetite stable and weight steady