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Although there is debate as to whether current GLP-1 agonists can readily cross the bloodbrain barrier, there is evidence to suggest that most do and exhibit CNS activity in humans [50]

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For patients with poorly controlled acromegaly, an SGLT-2 inhibitor was not recommended due to an increased risk of diabetic ketoacidosis (72)

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It doesn't stop degradation entirelynothing canbut it slows it to a crawl, extending the useful life of your research compound from mere hours or days to several weeks