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Uncommon Side Effects Less frequently reported effects include mild lightheadedness (potentially copper-related), temporary nausea or headache that typically resolves within hours, and rare transient fatigue at higher doses

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[DOI] [PubMed] [Google Scholar] 82.Dhande I., Ma W., Hussain T

These results along with the observation that inhibition of ERK1/2 together with GRK-arrestin mechanisms blunts rapid desensitization of MOR in locus coeruleus neurons suggests that ERK1/2 mechanisms may be important for regulation of MOR (Dang et al., 2009)

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