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Retatrutide activates GLP-1, GIP, and glucagon receptors, making it a triple agonist and the most receptor-diverse obesity compound currently in clinical development

Pregnancy Category C: Adequate and well-controlled studies have not been done in pregnant women

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For the CY 2026 OPPS/ASC proposed rule, CPT code 20982 had a geometric mean cost of around $18,375 and we proposed to continue to assign the procedure to APC 5115 (Level 5 Musculoskeletal Procedures), which has a proposed payment rate of around $13,254

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