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Ponadto istnieje ryzyko podania zanieczyszczonych substancji z czarnego rynku, nieoczekiwanych reakcji autoimmunologicznych i uszkodzenia zdrowia z powodu nieprawidowego dawkowania

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Depletion of SAMe and methionine can have significant consequences for health, disrupting the methylation pathway and leading to various health issues

They are produced by different types of cells and, once released in the body, induce specific reactions in adjacent cells (paracrine effect), in others far away (endocrine effect) or in those that have created them (autocrine effect)

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However, this is controversial, and more evidence is needed