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Figure 1 Data extraction First author name, country and year of publication, duration of the trial/weeks, duration of diabetes, age, gender, type and dose of GLP-1 agonists, total insulin dose in GLP-1 agonists and placebo arm, and the glycated hemoglobin in GLP-1 agonists and placebo were reported in tables and transferred manually to the RevMan, 5.4 for meta-analysis ( Tables 1 3 )

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Further, they added that if two main meals are present assuming that there is no more than 45 h between the two meals, any time can be preferred

Effects of renal impairment on the pharmacokinetics of the dual GIP and GLP-1 receptor agonist tirzepatide