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Three small cohort studies 148,149,150 examined associations between GLP-1RA use and metabolic changes in adults with a diagnosis of schizophrenia and comorbid diabetes and/or obesity on antipsychotics

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JAMA 311 , 18891900 (2014)

Sleep and circadian restoration Researchers specifically targeting sleep improvement might emphasize bedtime administration and potentially start with lower doses to assess individual sensitivity to melatonin-related effects

Our bodies take oxidative hits every single day from stress, poor sleep, pollution, processed foods, pesticides, and even normal metabolism

The peptide has a very short plasma half-life of approximately 3 minutes, which influences dosing frequency and timing considerations